Interferon

Endogenous proteins released by virally infected cells
يعنى اول اما الفيرس يهاجمها تطلعه لحمايه الخلايا المجاورة
سبحان الله
Types
1fn alpha &beta……………..responsible for antiviral effect
Produced by b^&t lymphocyte mq &fibroblast in response to viruses and cytokines
3.ifn gamma
Responsible for immunostimmulant effect produced gy t lymphocyte
3.pegylated ifn alpha (ifn alpha attached to poly ethylene glycol)
اقوى واطول فى المفعول وبيتاخد مرة واحدة فى الاسبوع تحت الجلد
Uses for ifn gamma
1hepatitis b &c
2.herpes
3.hiv
4.leukemia
5.external genital warts(condyloma lata)
Interferon beta-1a and interferon beta-1b are used to treat and control multiple sclerosis, an autoimmune disorder. This treatment is effective for slowing disease progression and activity in relapsing-remitting multiple sclerosis and reducing attacks in secondary progressive multiple sclerosis.[18]
PEGylated interferon alpha 2a (Egypt)
الاسم التجارى
Reiferon Retard
adverse effects are flu-like symptoms: increased body temperature, feeling ill, fatigue, headache, muscle pain, convulsion, dizziness, hair thinning, and depression. Erythema, pain and hardness on the spot of injection are also frequently observed. IFN therapy causes immunosuppression, in particular through neutropenia and can result in some infections manifesting in unusual ways.[26]
The immune effects of interferons have been exploited to treat several diseases. Agents that activate the immune system